P1380 on a GM vehicle means the powertrain control module (PCM) has detected a misfire but cannot confirm whether the road surface is rough because the rough road data signal is missing or invalid. The PCM uses this signal from the antilock brake system (ABS) module to distinguish genuine engine misfires from vibration caused by rough roads, and without it the misfire detection logic is compromised.
You can usually continue driving if the engine runs smoothly, but avoid heavy acceleration or towing until the fault is repaired. If the check engine light is flashing or the engine runs poorly, stop driving and seek service immediately to prevent catalytic converter damage.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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