P1381 on a GM vehicle means the powertrain control module (PCM) has detected engine misfire and also lost communication with the brake control module (BCM) over the controller area network (CAN) or serial data bus. The PCM stores this code when it cannot confirm misfire data from the brake system, often because the BCM is offline or the data bus is faulted.
You can usually drive the vehicle short distances to a repair shop, but avoid heavy acceleration or towing because the misfire may be real and the ABS/traction control may be disabled. If the engine runs poorly or multiple warning lights are on, stop driving and have it towed.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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