P1646 on GM vehicles indicates that the powertrain control module (PCM) has detected a fault on the class 2 serial data line that it uses to communicate with driver 1 devices, specifically line 6 of that network. The PCM monitors the voltage and message traffic on this line and sets the code when the signal is out of range, shorted, or missing entirely for a calibrated period.
Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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