P1621 on a GM vehicle means the powertrain control module (PCM) has detected an internal memory integrity fault, typically a checksum or flash memory error during its self-test. The PCM is the engine computer, and this code indicates it cannot reliably trust its own stored calibration or learned data, which can affect fuel delivery, ignition timing, and transmission shifting.
Limit driving to a short trip to a repair shop, because a PCM with corrupted memory can suddenly default to limp-home mode or stall without warning. Avoid heavy loads, towing, and highway speeds until the fault is diagnosed and corrected.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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