P1622 is a GM-specific code that indicates the powertrain control module (PCM) has detected an issue with the cylinder select signal circuit, which is used on engines with displacement-on-demand or active fuel management systems to enable or disable specific cylinders. The PCM monitors the circuit for expected voltage changes when it commands a transition between full and reduced cylinder operation, and it sets this code when the signal does not match the commanded state.
You can usually continue driving with P1622, but avoid heavy towing or aggressive acceleration until the fault is repaired, as the engine may stay in full-cylinder mode and consume more fuel. If you notice rough running or a flashing check engine light, stop driving and have the vehicle inspected promptly.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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