P1680 is a manufacturer-specific code stored by the powertrain control module (PCM) in GM vehicles when it detects a fault in the control circuit for Driver 5, which is one of the fuel injector driver outputs inside the PCM. The PCM monitors the electrical current through each injector driver and sets this code when the current falls outside the expected range, indicating an open circuit, short to ground, or short to voltage on that driver's circuit.
You can usually drive the vehicle short distances to a repair shop, but avoid heavy acceleration or towing because a misfiring cylinder can overheat the catalytic converter. If the engine runs very rough or flashes the check engine light, stop driving and have it towed.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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