P1666 on GM vehicles means the powertrain control module (PCM) has detected an electrical fault on the driver 3 line 6 circuit, which is a dedicated serial data line used for communication with a specific module or device. The PCM monitors the voltage and current on this line and sets the code when the signal is out of range, shorted, or missing entirely.
You can usually drive the vehicle with P1666 set, but avoid long trips or relying on features that may be affected by the communication fault, and address the code promptly to prevent a more serious no-start or safety system failure.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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