P1521 on GM vehicles means the powertrain control module detected that the transmission was engaged while the throttle angle was unusually high, typically during a forced downshift or when the accelerator pedal was held past a calibrated threshold. The computer compares throttle position sensor voltage with transmission range and gear signals, and it sets this code when the two do not agree with the expected driving state.
You can usually drive the vehicle to a shop if the transmission still shifts and the warning light is steady, but avoid hard acceleration and heavy towing until the fault is diagnosed. If the lamp flashes or the transmission slips or refuses to shift, stop driving and have it towed to prevent internal damage.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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