P1321 on a GM vehicle indicates that the powertrain control module has detected a fault on the electronic ignition system fault line, which is the communication circuit used to monitor and control the ignition control module or coil driver. The computer is not necessarily reporting a dead ignition component; it is flagging an abnormal voltage or signal condition on that dedicated diagnostic line.
Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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