DTC codes / P21xx · Fuel and air metering / P21E4
P21E4 indicates that the powertrain control module (PCM) has detected an abnormally low voltage on the control circuit for cylinder 5 injector B, which is the second injector assigned to that cylinder in a multi-injector or staged injection system. The PCM commands a fuel pulse but sees the circuit voltage stay below the expected threshold, so it sets this code and may disable that injector to protect the driver circuit.
Guidance is general and written for all OBD-II vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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