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DTC codes / P21xx · Fuel and air metering / P21D6
P21D6 indicates that the engine control module (ECM) has detected an open circuit or excessive resistance in the electrical path for cylinder 8's 'B' fuel injector circuit. This means the ECM cannot properly command that injector, which may cause a misfire or rough running, though some vehicles mask the symptom until higher loads.
Guidance is general and written for all OBD-II vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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