DTC codes / P21xx · Fuel and air metering / P21A5
P21A5 indicates that the powertrain control module has detected an air-fuel ratio imbalance on cylinder 10, meaning that cylinder's combustion is not contributing the expected amount of oxygen to the exhaust stream. The computer compares crankshaft speed fluctuations and upstream oxygen sensor feedback to identify which cylinder is misfiring or running at an incorrect air-fuel mixture.
Guidance is general and written for all OBD-II vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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