P1644 on GM vehicles indicates that the powertrain control module (PCM) has detected an abnormal condition in the throttle position (TP) output circuit, which is the signal path from the TP sensor to the PCM or from the PCM to other modules. The PCM monitors the voltage on this circuit and sets the code when the signal is out of expected range, stuck, or intermittent, often affecting throttle response and transmission shift feel.
Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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