P1421 on a GM vehicle means the powertrain control module (PCM) has detected a high-voltage condition on the intake air low pressure switch circuit, which is part of the secondary air injection (AIR) system on many GM applications. The switch is supposed to signal low intake air pressure during the AIR pump's operation, and a high-voltage reading tells the PCM that the circuit is open, shorted to voltage, or the switch is not responding as expected.
The vehicle is safe to drive with P1421 because the fault mainly affects emissions equipment and does not compromise engine safety or performance in most cases. Avoid long-term neglect, as continued driving with a disabled AIR system can lead to failed emissions inspections and may eventually affect cold-start emissions.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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