P1365 on a GM vehicle means the engine control module (ECM) has enabled the ignition control (IC) circuit for cylinder 5 but has not detected the expected voltage toggling on that circuit, indicating an open, short, or faulty component in the cylinder 5 ignition coil control path. The ECM monitors the IC circuit and expects it to switch between high and low states when the ignition coil is commanded to fire; failure to see that toggle sets this code.
You can usually drive the vehicle short distances to a repair shop, but avoid heavy acceleration or towing because a persistent misfire can overheat the catalytic converter and cause costly damage. If the check engine light is flashing, stop driving and have the vehicle towed.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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