P1220 on a GM vehicle means the powertrain control module (PCM) has detected a fault in the throttle position sensor (TPS) circuit, typically an out-of-range voltage or an implausible signal compared to the mass airflow and engine speed readings. The PCM monitors the TPS signal and sets this code when the voltage does not match expected values during key-on or running conditions.
You can usually drive the vehicle with P1220 set, but expect reduced performance and possible limp mode; avoid aggressive acceleration and have the fault diagnosed promptly to prevent worsening driveability or emissions issues.
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Guidance is general and written for GM vehicles. Exact tests and values vary by model, so confirm the fault before replacing parts.
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